P18 Experimental infection with low dose rhinovirus in asthma
نویسندگان
چکیده
منابع مشابه
Experimental Human Rhinovirus Infection
Double-blind trials were conducted in volunteers to evaluate the efficacy of the prophylactic 3,4-dihydro-1-isoquinolineacetamide hydrochloride (DIQA) treatment against rhinovirus type 24 challenge. Ten men received a 7-day course of DIQA treatment and 11 men received a placebo. The intranasal viral challenge dose was 10 mean tissue culture infective doses. The oral administration of 1 g precha...
متن کاملExperimental rhinovirus infection in volunteers.
Experimental viral disease studies in volunteers have clarified many aspects of the pathogenesis of human viral disease. Recently, interest has focused on rhinovirus-associated asthma exacerbations, and new volunteer studies have suggested that airway responsiveness (AR) is enhanced during a cold. For scientific, ethical and safety reasons, it is important to use validated methods for the prepa...
متن کاملComparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection.
BACKGROUND Asthma exacerbations are associated with human rhinovirus (HRV) infections, and more severe exacerbations are associated with HRV-C. We have previously shown that the HRV-C-specific antibody response is low in healthy adult sera and that most of the antibody to HRV-C is cross-reactive with HRV-A. OBJECTIVES To compare the antibody response to each HRV species in asthmatic and nonas...
متن کاملAirway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma
BACKGROUND The nature of bronchial mucosal inflammation and its physiologic and clinical significance in rhinovirus-induced asthma exacerbations is unclear. We investigated bronchial mucosal inflammatory response and its association with physiologic and clinical outcomes in an experimental model of rhinovirus-induced asthma exacerbations. METHODS We used immunohistochemistry methods to detect...
متن کاملRhinovirus Genome Evolution during Experimental Human Infection
Human rhinoviruses (HRVs) evolve rapidly due in part to their error-prone RNA polymerase. Knowledge of the diversity of HRV populations emerging during the course of a natural infection is essential and represents a basis for the design of future potential vaccines and antiviral drugs. To evaluate HRV evolution in humans, nasal wash samples were collected daily for five days from 15 immunocompe...
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ژورنال
عنوان ژورنال: Thorax
سال: 2010
ISSN: 0040-6376
DOI: 10.1136/thx.2010.150961.18